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Abstract #1250

Muscle mitochondrial dysfunction relates to decreased peripheral insulin sensitivity in female youth with type 2 diabetes

Mark S. Brown 1 , Abhinav Gupta 2 , Melanie Cree-Green 2 , Gregory Coe 2 , Amy Baumgartner 2 , Bradley R Newcomer 3 , and Kristen J Nadeau 2

1 Radiology, University of Colorado Anschutz, Aurora, CO, United States, 2 Pediatrics, University of Colorado Anschutz, Aurora, CO, United States, 3 Diagnostic and Clinical Sciences, University of Alabama, Birmingham, Alabama, United States

Insulin resistance (IR) is associated with mitochondrial dysfunction in adults with type 2 diabetes (T2D) but T2D in youth has a unique phenotype and is more common in females. We hypothesized that muscle IR, assessed using and hyperinsulinemic-euglycemic clamp techniques, would be associated with decreased mitochondrial function in adolescent females with T2D, as measured with dynamic 31P spectroscopy. T2D girls had slowed post-exercise ATP re-synthesis after exercise at an equal workload, relative to both lean and obese controls indicating decreased mitochondrial function following exercise. Further, rates of oxidative phosphorylation and mitochondrial capacity relate to insulin resistance in youth.

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