Abstract #1250
Muscle mitochondrial dysfunction relates to decreased peripheral insulin sensitivity in female youth with type 2 diabetes
Mark S. Brown 1 , Abhinav Gupta 2 , Melanie Cree-Green 2 , Gregory Coe 2 , Amy Baumgartner 2 , Bradley R Newcomer 3 , and Kristen J Nadeau 2
1
Radiology, University of Colorado Anschutz,
Aurora, CO, United States,
2
Pediatrics,
University of Colorado Anschutz, Aurora, CO, United
States,
3
Diagnostic
and Clinical Sciences, University of Alabama,
Birmingham, Alabama, United States
Insulin resistance (IR) is associated with mitochondrial
dysfunction in adults with type 2 diabetes (T2D) but T2D
in youth has a unique phenotype and is more common in
females. We hypothesized that muscle IR, assessed using
and hyperinsulinemic-euglycemic clamp techniques, would
be associated with decreased mitochondrial function in
adolescent females with T2D, as measured with dynamic
31P spectroscopy. T2D girls had slowed post-exercise ATP
re-synthesis after exercise at an equal workload,
relative to both lean and obese controls indicating
decreased mitochondrial function following exercise.
Further, rates of oxidative phosphorylation and
mitochondrial capacity relate to insulin resistance in
youth.
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