Assessment of Experimental Cerebral Malaria Using Diffusion Tensor Imaging at Ultra-High Magnetic Field
Teodora-Adriana Perles-Barbacaru 1,2 , Bruno Miguel de Brito Robalo 1,3 , Emilie Pecchi 1,2 , Georges Emile Raymond Grau 4 , Monique Bernard 1,2 , and Angle Viola 1,2
Centre de Rsonance Magntique Biologique et
Mdicale, CRMBM UMR CNRS 7339, Marseille, France,
Universit, Marseille, France,
of Lisbon, Institute of Biophysics and Biomedical
Engineering, Lisbon, Portugal,
of Pathology, Sydney Medical School, The University of
Sydney, Camperdown, Australia
Changes in brain tissue microstructure in murine
cerebral malaria were investigated with DTI. Mice were
imaged before disease and after infestation with
Plasmodium Berghei ANKA. A segmented EPI technique was
used for brain DTI acquisitions. S
, FA, ADC,
were generated. Early after infestation, FA was
significantly deceased in specific white matter tracts,
when the neurological signs were not yet detectable.
Increases in ADC and radial diffusitivities occurred
during the peak of the disease. Loss of tissue
anisotropy is a new hallmark of the disease that may
help improve our understanding of CM pathogenesis.
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