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Abstract #1252

Assessment of Experimental Cerebral Malaria Using Diffusion Tensor Imaging at Ultra-High Magnetic Field

Teodora-Adriana Perles-Barbacaru 1,2 , Bruno Miguel de Brito Robalo 1,3 , Emilie Pecchi 1,2 , Georges Emile Raymond Grau 4 , Monique Bernard 1,2 , and Angle Viola 1,2

1 Centre de Rsonance Magntique Biologique et Mdicale, CRMBM UMR CNRS 7339, Marseille, France, 2 Aix-Marseille Universit, Marseille, France, 3 University of Lisbon, Institute of Biophysics and Biomedical Engineering, Lisbon, Portugal, 4 Department of Pathology, Sydney Medical School, The University of Sydney, Camperdown, Australia

Changes in brain tissue microstructure in murine cerebral malaria were investigated with DTI. Mice were imaged before disease and after infestation with Plasmodium Berghei ANKA. A segmented EPI technique was used for brain DTI acquisitions. S 0 , FA, ADC, λ 1 , λ 2 and λ 3 maps were generated. Early after infestation, FA was significantly deceased in specific white matter tracts, when the neurological signs were not yet detectable. Increases in ADC and radial diffusitivities occurred during the peak of the disease. Loss of tissue anisotropy is a new hallmark of the disease that may help improve our understanding of CM pathogenesis.

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