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Abstract #1253

Custom-Fit, 3D-Printed Marmoset Brain Holders for Comparison of Histology with MRI

Joseph Guy 1,2 , Pascal Sati 1 , Steven Jacobson 3 , Afonso C Silva 4 , and Daniel S Reich 1

1 Translational Neuroradiology Unit, Neuroimmunology Branch, National Institute of Neurologic Disorders and Stroke, Bethesda, MD, United States, 2 Department of Biochemistry, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom, 3 Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurologic Disorders and Stroke, Bethesda, MD, United States, 4 Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurologic Disorders and Stroke, Bethesda, MD, United States

MRI and histology are two very different but uniquely useful approaches to investigate diseases in cerebral tissues. However, due to the inherent differences between the methods (particularly image resolution), it is difficult to combine them together to investigate small-scale features/pathology. This can be overcome with the use of custom-fit, 3D-printed cradles/slicers that maintain alignment and orientation of brains between MRI and tissue cutting. We applied this method in marmoset brains and obtained a highly precise comparison between in vivo MRI, ex vivo MRI, and histology.

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