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Abstract #1254

Imaging the human brain with dissolved xenon MRI at 1.5T

Madhwesha Rao 1 , Neil Stewart 1 , Graham Norquay 1 , Paul Griffiths 1 , and Jim Wild 1

1 University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Hyperpolarized 129Xe when inhaled into the lungs, dissolves into the blood and is transferred to the brain by systemic circulation. The aim of this work was to demonstrate high-resolution spectroscopy and 2D gradient echo imaging of Hyperpolarized 129Xe dissolved in the human brain at 1.5 T for the first time. In this study, we demonstrate HP 129Xe as a safe, non-invasive contrast agent for imaging of xenon (blood) delivery to different compartments of the human brain in vivo.

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