Imaging the human brain with dissolved xenon MRI at 1.5T
Madhwesha Rao 1 , Neil Stewart 1 , Graham Norquay 1 , Paul Griffiths 1 , and Jim Wild 1
University of Sheffield, Sheffield, South
Yorkshire, United Kingdom
Hyperpolarized 129Xe when inhaled into the lungs,
dissolves into the blood and is transferred to the brain
by systemic circulation. The aim of this work was to
demonstrate high-resolution spectroscopy and 2D gradient
echo imaging of Hyperpolarized 129Xe dissolved in the
human brain at 1.5 T for the first time. In this study,
we demonstrate HP 129Xe as a safe, non-invasive contrast
agent for imaging of xenon (blood) delivery to different
compartments of the human brain in vivo.
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