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Abstract #1255

4D Phase Contrast EPI for assessing 3D volumetric strain rate in the human brain over the cardiac cycle

Nils Noorman 1 , Sebastian Hirsch 2 , Jrgen Braun 3 , Peter R. Luijten 1 , Ingolf Sack 2 , and Jaco J.M. Zwanenburg 1

1 Department of Radiology, University Medical Center, Utrecht, Utrecht, Netherlands, 2 Department of Radiology, Charit - Universittsmedizin Berlin, Berlin, Germany, 3 Institute of Medical Informatics, Charit - Universittsmedizin Berlin, Berlin, Germany

The pulsating heart induces volumetric strain pulsations in the brain, which drive the interstitial transport of metabolites and waste products. This feasibility study mapped these volumetric strain rates for the first time with a time resolved 3-dimensional phase contrast (3D PCA) sequence (0.3 cm/s encoding velocity), over the entire brain and cardiac cycle (74 ms temporal resolution). The shapes of the strain rate curves obtained in four volunteers were similar to previous studies using different techniques. However, the magnitude was approximately 5 times larger, requiring further validation before using this technique as a tool for studying brain (patho)physiology.

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