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Abstract #1256

Kinetic oscillatory stimulation (KOS) in the nasal cavity studied by resting-state fMRI

Tie-Qiang Li 1 , Rolf Hallin 2 , and Jan-Erik Juto 3

1 Department of Medical Physics, Karolinska University Hospital, Karolinska Huddinge, Stockholm, Sweden, 2 Department of Neurophysiology, Karolinska University Hospital, Karolinska Huddinge, stockholm, Sweden, 3 Department of CLINTEC, Karolinska Institute, Huddinge, stockholm, Sweden

Kinetic oscillatory stimulation (KOS) in the nasal cavity has been shown to be effective for treating acute migraine and inflammation. We aimed to better understand the neurological mechanisms underlying KOS treatment. We used a resting-state fMRI protocol that fits the treatment inside MRI scanners and a metric based on the number of significant functional connections to quantify BOLD response to KOS treatment. Our results demonstrate that migraine is associated with enhanced functional modulations within the control network of the autonomous nervous system and KOS treatment results in significantly different responses between normal controls and migraine patients.

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