Abstract #1261
Inspiration drives cerebrospinal fluid flow in humans
Steffi Dreha-Kulaczewski 1 , Arun Jospeh 2,3 , Klaus-Dietmar Merboldt 2 , Hans Ludwig 4 , Jutta Gaertner 1 , and Jens Frahm 2,3
1
Department of Pediatrics and Adolescent
Medicine, Division of Pediatric Neurology, University
Medical Center, Goettingen, Germany,
2
Biomedizinische
NMR Forschungs GmbH am Max-Planck-Institut fuer
biophysikalische Chemie, Goettingen, Germany,
3
partner
site Goettingen, German Center for Cardiovascular
Research, Germany,
4
Department of
Neurosurgery, Division of Pediatric Neurosurgery,
University Medical Center Goettingen, Germany
The mechanisms behind cerebrospinal fluid (CSF) flow in
humans are still not fully known. We applied a novel
real-time MRI technique at high spatial and temporal
resolution in healthy subjects to study through-plane
CSF flow in the third ventricle. Significant CSF flow
was observed exclusively with inspiration (forced
breathing protocol), whereas breath hold suppressed it.
A small modulating flow component was ascribed to
cardiac pulsation. The present results unambiguously
identify inspiration as the most important driving force
for CSF flow. This approach opens new opportunities to
study the pathophysiology of various forms of
hydrocephalus and to design appropriate therapeutic
strategies.
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