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Abstract #1270

Arterial spin labeling perfusion imaging performed in acute perinatal stroke reveals hyperperfusion in association with cerebral ischemic injury

Christopher G. Watson 1,2 , Mathieu Dehaes 3 , Borjan A. Gagoski 3 , P. Ellen Grant 3,4 , and Michael J. Rivkin 1,4

1 Neurology, Boston Children's Hospital, Boston, MA, United States, 2 Graduate Program for Neuroscience, Boston University, Boston, MA, United States, 3 Newborn Medicine, Boston Children's Hospital, MA, United States, 4 Radiology, Boston Children's Hospital, Boston, MA, United States

Arterial spin labeling (ASL) has not been extensively used in the acute stage of neonatal stroke. We aimed to establish whether acquiring ASL in neonatal stroke is feasible, and determine if distinct perfusion patterns are evident in arterial and venous stroke types. Of 23 neonates with acceptable ASL data, we found that hyperperfusion was more common in arterial stroke, and hypoperfusion was only present in venous stroke. Additionally, clinical seizures occurred only in arterial stroke. We conclude that ASL acquisition is feasible in neonates with acute stroke. Hyperperfusion may be due to reperfusion or to increased neuronal activity in seizures.

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