Arterial spin labeling perfusion imaging performed in acute perinatal stroke reveals hyperperfusion in association with cerebral ischemic injury
Christopher G. Watson 1,2 , Mathieu Dehaes 3 , Borjan A. Gagoski 3 , P. Ellen Grant 3,4 , and Michael J. Rivkin 1,4
Neurology, Boston Children's Hospital,
Boston, MA, United States,
Program for Neuroscience, Boston University, Boston, MA,
Medicine, Boston Children's Hospital, MA, United States,
Boston Children's Hospital, Boston, MA, United States
Arterial spin labeling (ASL) has not been extensively
used in the acute stage of neonatal stroke. We aimed to
establish whether acquiring ASL in neonatal stroke is
feasible, and determine if distinct perfusion patterns
are evident in arterial and venous stroke types. Of 23
neonates with acceptable ASL data, we found that
hyperperfusion was more common in arterial stroke, and
hypoperfusion was only present in venous stroke.
Additionally, clinical seizures occurred only in
arterial stroke. We conclude that ASL acquisition is
feasible in neonates with acute stroke. Hyperperfusion
may be due to reperfusion or to increased neuronal
activity in seizures.
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