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Abstract #1272

Longitudinal Cortical Maturation in Typically Developing Infants and Children

Justin M Remer 1 , Douglas C Dean III 1,2 , Sara D'Arpino 1 , Elise Croteau-Chonka 1 , Holly Dirks 1 , and Sean C.L. Deoni 1,3

1 Advanced Baby Imaging Lab, School of Engineering, Brown University, Providence, RI, United States, 2 Waisman Lab for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, United States, 3 Department of Pediatric Radiology, Children's Hospital Colorado, Aurora, CO, United States

Cortical development is a rapid and dynamic process that has been shown been shown to be a predictive measure of cognitive development in adolescents. Longitudinal developmental trajectories of cortical thickness from 163 healthy, typically developing infants and children were characterized using non-linear mixed effects modeling and shown to exhibit both linear and non-linear behavior. In addition, differential cortical development based on early learning composite, a surrogate measure of IQ, was observed in three specific brain regions. Our results provide insight into the complexities behind cortical maturation and provide an important foundation for understanding typical cortical development.

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