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Abstract #1274

Mapping the myelin g-ratio during neurodevelopment

Douglas Dean 1,2 , Elise Croteau-Chonka 2 , Holly Dirks 2 , Andrew L. Alexander 1 , and Sean Deoni 2,3

1 Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, 2 Engineering, Brown University, Providence, Rhode Island, United States, 3 Childrens Hospital Colorado, Dever, Colorado, United States

Myelination is a critical process of white matter development. While several neuroimaging techniques have been used to study white matter development, no prior studies have directly examine the microstructural properties of myelin. In this work, we present an alternative approach, combining multicomponent relaxometry and NODDI data, to measure the myelin g-ratio and for the first time present developmental trajectories of the myelin g-ratio during neurodevelopment.

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