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Abstract #1275

Neural Correlates of the Longitudinal Development of Phonological Processing in Early Childhood

Andrea S. Miele 1,2 , Holly Dirks 2 , Dannielle John Whiley 2 , Terry Harrison-Goldman 1,3 , Viren D'Sa 3 , and Sean Deoni 2,4

1 Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, United States, 2 Advanced Baby Imaging Laboratory, Brown University, Providence, Rhode Island, United States, 3 Pediatrics, Neurodevelopmental Center, MHRI, Pawtucket, Rhode Island, United States, 4 Pediatric Radiology, Children's Hospital Colorado, Colorado, United States

Dyslexia is a language-based learning disability characterized by deficits in phonological processing, a set of skills considered essential for reading acquisition. To our knowledge, no study has yet investigated the relationship between myelin maturation in toddlers and later phonological awareness skills. Participants were grouped by level of performance on a well-researched and validated measure of phonological awareness (PA), and mixed effects modeling utilized to plot MWF growth curves. Longitudinal trajectories revealed increasing MWF by age. High PA performers had greater myelin content (p<.05) in the temporal lobe but less myelin content (p<.05) in the frontal lobe compared to low performers.

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