Abstract #1275
Neural Correlates of the Longitudinal Development of Phonological Processing in Early Childhood
Andrea S. Miele 1,2 , Holly Dirks 2 , Dannielle John Whiley 2 , Terry Harrison-Goldman 1,3 , Viren D'Sa 3 , and Sean Deoni 2,4
1
Psychiatry and Human Behavior, Alpert
Medical School of Brown University, Providence, Rhode
Island, United States,
2
Advanced
Baby Imaging Laboratory, Brown University, Providence,
Rhode Island, United States,
3
Pediatrics,
Neurodevelopmental Center, MHRI, Pawtucket, Rhode
Island, United States,
4
Pediatric
Radiology, Children's Hospital Colorado, Colorado,
United States
Dyslexia is a language-based learning disability
characterized by deficits in phonological processing, a
set of skills considered essential for reading
acquisition. To our knowledge, no study has yet
investigated the relationship between myelin maturation
in toddlers and later phonological awareness skills.
Participants were grouped by level of performance on a
well-researched and validated measure of phonological
awareness (PA), and mixed effects modeling utilized to
plot MWF growth curves. Longitudinal trajectories
revealed increasing MWF by age. High PA performers had
greater myelin content (p<.05) in the temporal lobe but
less myelin content (p<.05) in the frontal lobe compared
to low performers.
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