Abstract #1276
18q- Brain Development with Age and the Effect of Deletion Size
Xi Tan 1 , Jannine Cody 2 , and Jack L Lancaster 1
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States,
2
Department
of Pediatrics, University of Texas Health Science Center
at San Antonio, San Antonio, TX, United States
18q- is a chromosomal disease. People with 18q- miss
part of the long arm (q arm) of one copy of chromosome
18. Since people with 18q- are typically mental retarded
and developmental delayed, this study investigated whole
brain volume, grey matter volume and white matter volume
development on the age rang 0-25 years old, and the
linear effect of deletion size on the these volumes. It
proved that deletion size have a negatively linear
effect on these volumes, and 18q- volumes grow quicker
to reach equilibrium volumes, but their equilibrium
volumes are smaller than normally developed control
subjects.
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