Abstract #1278
Developmental changes in neurochemical profiles of the mouse midbrain and hippocampus
Ivan Tkac 1 , Kathleen Czerniak 2 , Lanka Dasanayaka 2 , Biplab Dasgupta 3 , and Raghavendra Rao 2
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States,
2
Department
of Pediatrics, University of Minnesota, Minneapolis, MN,
United States,
3
Division
of Hematology/Oncology, Cincinnati Children's Hospital,
Cincinnati, OH, United States
Mouse models are often used in studies of the brain
development. Rapid postnatal changes in neural cell
populations, their size and their maturation result in
major changes in metabolite levels. Therefore, the
knowledge of regionally specific neurochemical changes
in normal mouse brain development is required. In this
study we use
1
H
MRS at 9.4T to quantify neurochemical profiles of the
midbrain and hippocampus in a common C57BL/6 mouse
strain at postnatal days (P)10 and P28. These
neurochemical profiles and their changes are
distinctively different. Relatively high levels of urea
were detected in the brain at P10.
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