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Abstract #1278

Developmental changes in neurochemical profiles of the mouse midbrain and hippocampus

Ivan Tkac 1 , Kathleen Czerniak 2 , Lanka Dasanayaka 2 , Biplab Dasgupta 3 , and Raghavendra Rao 2

1 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2 Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, 3 Division of Hematology/Oncology, Cincinnati Children's Hospital, Cincinnati, OH, United States

Mouse models are often used in studies of the brain development. Rapid postnatal changes in neural cell populations, their size and their maturation result in major changes in metabolite levels. Therefore, the knowledge of regionally specific neurochemical changes in normal mouse brain development is required. In this study we use 1 H MRS at 9.4T to quantify neurochemical profiles of the midbrain and hippocampus in a common C57BL/6 mouse strain at postnatal days (P)10 and P28. These neurochemical profiles and their changes are distinctively different. Relatively high levels of urea were detected in the brain at P10.

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