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Abstract #1279

Metabolite distributions in human aging brain - a study with short-TE whole brain MR spectroscopic imaging

Xiao-Qi Ding 1 , Helen Maghsudi 1 , Andrew A. Maudsley 2 , Mohammad Sabati 2 , Sulaiman Sheriff 2 , Martin Schtze 1 , Paul Bronzlik 1 , and Heinrich Lanfermann 1

1 Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Lower Saxony, Germany, 2 Department of Radiology, University of Miami School of Medicine, Miami, FL, United States

Metabolite concentrations in multiple brain structures of 60 healthy adults (21 - 70 years) were measured by using a short TE (17.6 ms) whole brain MR spectroscopic imaging (wbMRSI). The distributions as well as the age-related changes of brain metabolites NAA, tCho, tCr, mI, and Glx were regional and metabolite dependent. The most age-related changes were observed in metabolite NAA with age-related decreases in seven of thirteen selected brain structures and the cerebrum revealed more local metabolic changes than that in cerebellum.

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