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Abstract #1280

Novel probabilistic neonatal cortical brain atlas

Bonnie Alexander 1 , Andrea Murray 1 , Jian Chen 1,2 , Wai Yen Loh 1,3 , Claire Kelly 1 , Richard Beare 1 , Lillian Gabra Fam 1,4 , Peter Anderson 1,4 , Lex Doyle 1,5 , Alicia Spittle 1,5 , Jeanie Cheong 1,5 , Marc Seal 1,4 , and Deanne Thompson 1,3

1 Murdoch Childrens Research Institute, Melbourne, Victoria, Australia, 2 Dept of Medicine, Monash University, Melbourne, Australia, 3 Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 4 Dept of Paediatrics, The University of Melbourne, Melbourne, Australia, 5 Royal Women's Hospital, Melbourne, Australia

This project addresses the need for a high quality neonatal brain atlas attuned to accommodate tissue types and morphological subtleties characteristic of this developmental stage. T2 MRI scans of 3 healthy term-born neonates were used. Cortical gray matter was segmented using an in-house pipeline incorporating the unified segmentation process implemented in SPM8. 33 cortical areas per hemisphere were manually traced corresponding to those in the Desikan-Killiany adult brain atlas. A structural template was generated using symmetric diffeomorphic transformation, and structure probability maps were constructed. The atlas produced will be incorporated into a freely accessible infant segmentation and parcellation toolbox.

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