Abstract #1281
Characterisation of sensori-motor CBF and BOLD functional responses during early development with dual-echo pCASL and fMRI
Thomas Alderliesten 1,2 , Esben Thade Petersen 3 , Manon JNL Benders 1,2 , Petra MA Lemmers 2 , Alessandro Allievi 4 , Julia Wurie 1 , Serena J Counsell 1 , Etienne Burdet 4 , A. David Edwards 1,4 , Jo V Hajnal 1,5 , and Tomoki Arichi 1,4
1
Centre for the Developing Brain, King's
College London, London, London, United Kingdom,
2
Department
of Neonatology, University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands,
3
Department
of Radiology, University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands,
4
Department
of Bioengineering, Imperial College London, London,
United Kingdom,
5
Division
of Imaging Sciences and Biomedical Engineering, King's
College London, London, United Kingdom
Functional MRI (fMRI) is being increasingly used in
infants. However, the underlying blood oxygen level
dependent (BOLD) contrast is qualitative in nature, and
its biophysical origins in this population are poorly
understood. By measuring cerebral blood flow, Arterial
Spin Labeling (ASL) can add a quantitative dimension to
fMRI. We therefore aimed to simultaneously measure
functional ASL and BOLD responses following
somatosensory stimulation (passive wrist movement) in
infants during their first year by using a dual echo
pCASL sequence. Eight infants were studied; ASL
responses largely overlaid BOLD responses, but were less
diffuse and more localized to the cortex.
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