Meeting Banner
Abstract #1281

Characterisation of sensori-motor CBF and BOLD functional responses during early development with dual-echo pCASL and fMRI

Thomas Alderliesten 1,2 , Esben Thade Petersen 3 , Manon JNL Benders 1,2 , Petra MA Lemmers 2 , Alessandro Allievi 4 , Julia Wurie 1 , Serena J Counsell 1 , Etienne Burdet 4 , A. David Edwards 1,4 , Jo V Hajnal 1,5 , and Tomoki Arichi 1,4

1 Centre for the Developing Brain, King's College London, London, London, United Kingdom, 2 Department of Neonatology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 3 Department of Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 4 Department of Bioengineering, Imperial College London, London, United Kingdom, 5 Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Functional MRI (fMRI) is being increasingly used in infants. However, the underlying blood oxygen level dependent (BOLD) contrast is qualitative in nature, and its biophysical origins in this population are poorly understood. By measuring cerebral blood flow, Arterial Spin Labeling (ASL) can add a quantitative dimension to fMRI. We therefore aimed to simultaneously measure functional ASL and BOLD responses following somatosensory stimulation (passive wrist movement) in infants during their first year by using a dual echo pCASL sequence. Eight infants were studied; ASL responses largely overlaid BOLD responses, but were less diffuse and more localized to the cortex.

This abstract and the presentation materials are available to members only; a login is required.

Join Here