Abstract #1283
Modulation of resting-state brain networks in newborns by heel prick
Lara Lordier 1 , Frdric Grouiller 2 , Dimitri Van de Ville 2,3 , Ana Sancho Rossignol 4 , Maria Isabel Cordero 4 , Franois Lazeyras 2 , Franois Ansermet 4 , and Petra S. Hppi 1
1
Division of Development and Growth,
Department of Pediatrics, University of Geneva, Geneva,
Geneva, Switzerland,
2
Department
of Radiology and Medical Informatics, Geneva University
Hospital, Geneva, Switzerland,
3
Institute
of Bioengineering, Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland,
4
Division
of Child and Adolescent Psychiatry, Department of
Pediatrics, University of Geneva, Geneva, Switzerland
Previous studies in adults reported that spontaneous
brain activity can be modulated by learning, training,
but also by behavioral states, which is supporting the
idea that low-frequency BOLD signal fluctuations are
modulated by recent experience. We mapped resting state
networks (RSNs) in nine newborns and investigate if
these low-frequency BOLD signal fluctuations were
modified after a heel prick. We observed RSNs similar to
those previously found in adults and infants.
Furthermore, we showed an increased connectivity between
basal ganglia and orbitofrontal components reflecting
the integration and modulation of the pain experience.
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