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Abstract #1288

Subcortical rather than cortical changes mediate the clinical profile on ADHD boys at an earlier stage

Qi Liu 1 , Lizhou Chen 1 , Ying Chen 2 , Xinyu Hu 1 , Ming Zhou 1 , Fei Li 1 , Lanting Guo 2 , Qiyong Gong 1 , and Xiaoqi Huang 1

1 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2 Deptmeny of Psychiatry, West China Hospital of Sichuan University, P.R.China, Chengdu, Sichuan, China

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood. The present study aimed to explore the brain structural changes between medicated-nave male ADHD and healthy controls. Finally, we found that subcortical volumes of bilateral putamen and amygdala were smaller in ADHD group, and those changes were significantly correlated with clinical measurements for behavioral problems and some specific executive domains. This suggested that putamen and amygdala may play key roles in ADHD.

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