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Abstract #1289

Age Related Changes of the Interrelationships of White Matter in Autism Spectrum Disorder

Douglas Dean 1 , Brittany Travers 1 , Erin Bigler 2 , Molly Prigge 3 , Alyson Froehlich 3 , Nicholas Lange 4 , Janet Lainhart 1 , and Andrew Alexander 1

1 Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, 2 Brigham Young University, Provo, UT, United States, 3 University of Utah, Salt Lake City, UT, United States, 4 Harvard School of Medicine and McLean Hospital, Belmont, MA, United States

Brain imaging findings in children with autism spectrum disorder (ASD) suggest the disorder is associated with altered brain development and disrupted structural and functional brain connectivity," which implies atypical white matter microstructure in at least some parts of the brain in ASD. However, it is unclear how homogeneous the structural organization of the white matter microstructure is within the brains of individuals with ASD at different ages. In this work, we examine correlations among the microstructure of different white matter tracts in childhood and adulthood in ASD compared to typical development.

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