Abstract #1290
Functional connectivity of altered grey matter regions in Autism Spectrum Disorder: correlations with clinical testing
Letizia Casiraghi 1,2 , Fulvia Palesi 2,3 , Gloria Castellazzi 2,4 , Andrea De Rinaldis 2,4 , Carol Di Perri 5 , Claudia AM Wheeler-Kingshott 6 , and Egidio D'Angelo 1,2
1
Department of Brain and Behavioral Sciences,
University of Pavia, Pavia, PV, Italy,
2
Brain
Connectivity Center, C. Mondino National Neurological
Institute, Pavia, PV, Italy,
3
Department of
Physics, University of Pavia, Pavia, PV, Italy,
4
Department
of Electrical, Computer and Biomedical Engineering,
University of Pavia, Pavia, PV, Italy,
5
Department
of Brain and Behavioural Sciences, University of Pavia,
Pavia, PV, Italy,
6
NMR
Research Unit, Department of Neuroinflammation, Queen
Square MS Centre, UCL Institute of Neurology, London,
England, United Kingdom
Autism Spectrum Disorder (ASD) children present atypical
brain functioning. We assessed the functional
connectivity of altered grey matter (GM) regions. Areas
of increased volume in ASD presented FC increments and
reductions whereas reduced density areas presented FC
reductions only. Correlations between FC and clinical
scores indicate that the more extreme the FC the more
severe the impairment. Our results support the idea that
temporal and subcortical areas are responsible for the
sensory integration and emotional deficits while
occipital areas and insula are strongly involved in
deficit linked to the integration of visual stimuli and
self-awareness information.
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