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Abstract #1296

Diffusion tensor imaging metrics may be less sensitive than volumetry/morphology in measuring differences in mouse models related to autism.

Jacob Ellegood 1 , Jan Scholz 1 , Mark Henkelman 1,2 , and Jason P Lerch 1,2

1 Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada, 2 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Current research has shown volumetric differences in 26 different mouse models related to autism. The purpose of this work is to use diffusion tensor imaging (DTI) to further examine the structural connectivity differences in 13 of those mouse models to further investigate the white matter differences. Surprisingly only 3 of the 13 models had differences in fractional anisotropy and mean diffusivity.

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