Diffusion tensor imaging metrics may be less sensitive than volumetry/morphology in measuring differences in mouse models related to autism.
Jacob Ellegood 1 , Jan Scholz 1 , Mark Henkelman 1,2 , and Jason P Lerch 1,2
Mouse Imaging Centre, Hospital for Sick
Children, Toronto, Ontario, Canada,
Biophysics, University of Toronto, Toronto, Ontario,
Current research has shown volumetric differences in 26
different mouse models related to autism. The purpose of
this work is to use diffusion tensor imaging (DTI) to
further examine the structural connectivity differences
in 13 of those mouse models to further investigate the
white matter differences. Surprisingly only 3 of the 13
models had differences in fractional anisotropy and mean
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