Abstract #1297
Diffusion tensor imaging to assess gray and white matter microstructural brain abnormalities in a feline model of alpha-mannosidosis
Manoj Kumar 1 , Jeff T Duda 1 , Sea-Young Yoon 2 , Jessica Bagel 3 , Patricia ODonnell 3 , Charles Vite 3 , Stephen Pickup 1 , James C Gee 1 , John H Wolfe 2 , and Harish Poptani 1
1
Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States,
2
Research
Institute of the Children's Hospital of Philadelphia,
Philadelphia, Pennsylvania, United States,
3
School
of Veterinary Medicine, University of Pennsylvania,
Philadelphia, PA, United States, Pennsylvania, United
States
Alpha-mannosidosis is an autosomal recessively inherited
lysosomal storage disorder, caused by deficiency of the
enzyme alpha mannosidase. We performed ex-vivo diffusion
tensor imaging (DTI) and in vivo DTI on AMD affected and
wild type cat brains to assess brain abnormalities. A
multi-atlas approach was used to generate a brain
template and process the ex vivo DTI data. The
probabilistic label method was used to measure
fractional anisotropy (FA) and mean diffusivity (MD)
values from gray and white matters from whole brain.
Region of interest based DTI data analysis was also from
ex vivo and in vivo DTI from six gray and five white
matter regions. Significantly reduced FA was observed
from both the ex vivo and in vivo DTI data from all the
white matter in AMD affected cats may be suggestive of
gliosis or demyelination. Some of the analyzed gray
matter also demonstrates significantly reduced FA in AMD
affected cats.
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