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Abstract #1298

Increased frontal irregularity of resting state fMRI in children with autism spectrum disorders

Robert X Smith 1 , Devora Beck-Pancer 2 , Rosemary McCarron 2 , Kay Jann 1 , Leanna Hernandez 2 , Mirella Dapretto 2 , and Danny JJ Wang 1

1 Neurology, UCLA, Los Angeles, CA, United States, 2 Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States

We investigate the relationship between local neural activity and network organization in a cohort of children with autism spectrum disorders (ASD) and typically developing children. We employ wavelet-based regularity analysis, a recently developed measure of resting-state functional MRI signal dynamics, in conjunction with seed-based functional connectivity. We find widespread regions across the prefrontal cortex in children with ASD that exhibit 1) increased signal irregularity, 2) bilateral decreases in long-range correlations to posterior areas, and 3) disorganized increases to local frontal regions. These results provide strong evidence implicating atypical neural activity in the disruption of long-range association pathways.

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