Abstract #1298
Increased frontal irregularity of resting state fMRI in children with autism spectrum disorders
Robert X Smith 1 , Devora Beck-Pancer 2 , Rosemary McCarron 2 , Kay Jann 1 , Leanna Hernandez 2 , Mirella Dapretto 2 , and Danny JJ Wang 1
1
Neurology, UCLA, Los Angeles, CA, United
States,
2
Psychiatry
and Biobehavioral Sciences, UCLA, Los Angeles, CA,
United States
We investigate the relationship between local neural
activity and network organization in a cohort of
children with autism spectrum disorders (ASD) and
typically developing children. We employ wavelet-based
regularity analysis, a recently developed measure of
resting-state functional MRI signal dynamics, in
conjunction with seed-based functional connectivity. We
find widespread regions across the prefrontal cortex in
children with ASD that exhibit 1) increased signal
irregularity, 2) bilateral decreases in long-range
correlations to posterior areas, and 3) disorganized
increases to local frontal regions. These results
provide strong evidence implicating atypical neural
activity in the disruption of long-range association
pathways.
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