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Abstract #1299

The healthy human cerebellum engaging in complex patterns: An fMRI study

Adnan A.S. Alahmadi 1,2 , Matteo Pardini 1,3 , Rebecca S Samson 1 , Karl J Friston 4 , Ahmed T Toosy 1,5 , Egidio DAngelo 6,7 , and Claudia A.M. Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, 3 Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy, 4 Wellcom Centre for Imaging Neuroscience, UCL, Institute of Neurology, London, United Kingdom, 5 NMR Research Unit, Department of Brain Repair and Rehabilitation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 6 C. Mondino National, Neurological Institute, Pavia, Italy, 7 Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

We explored non-linear BOLD responses in the cerebellum using a grip task, with five grip forces. Linear responses were observed in the anterior lobules and non-linear responses were localized in the posterior lobules. Previous studies have shown that the cerebellum is involved in different non-motor functions and interestingly our findings confirm that the cerebellum behavior in response to a complex paradigm reflects the presence of an organized structure, similarly to what has been suggested by cortical fMRI studies. In particular, higher order effects are localized in the posterior of the cerebellum known to be involved in executive and sensory functions.

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