Abstract #1299
The healthy human cerebellum engaging in complex patterns: An fMRI study
Adnan A.S. Alahmadi 1,2 , Matteo Pardini 1,3 , Rebecca S Samson 1 , Karl J Friston 4 , Ahmed T Toosy 1,5 , Egidio DAngelo 6,7 , and Claudia A.M. Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, England, United Kingdom,
2
Department
of Diagnostic Radiology, Faculty of Applied Medical
Science, KAU, Jeddah, Saudi Arabia,
3
Department
of Neurosciences, Ophthalmology and Genetics, University
of Genoa, Genoa, Italy,
4
Wellcom
Centre for Imaging Neuroscience, UCL, Institute of
Neurology, London, United Kingdom,
5
NMR
Research Unit, Department of Brain Repair and
Rehabilitation, Queen Square MS Centre, UCL Institute of
Neurology, London, United Kingdom,
6
C.
Mondino National, Neurological Institute, Pavia, Italy,
7
Department
of Brain and Behavioural Sciences, University of Pavia,
Pavia, Italy
We explored non-linear BOLD responses in the cerebellum
using a grip task, with five grip forces. Linear
responses were observed in the anterior lobules and
non-linear responses were localized in the posterior
lobules. Previous studies have shown that the cerebellum
is involved in different non-motor functions and
interestingly our findings confirm that the cerebellum
behavior in response to a complex paradigm reflects the
presence of an organized structure, similarly to what
has been suggested by cortical fMRI studies. In
particular, higher order effects are localized in the
posterior of the cerebellum known to be involved in
executive and sensory functions.
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