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Abstract #1300

fMRI Demonstrates Response Selectivity to the Behaviorally Relevant Sounds in the Midbrain

Jevin W. Zhang 1,2 , Patrick P. Gao 1,2 , Shu-Juan Fan 1,2 , Dan H. Sanes 3 , and Ed X. Wu 1,2

1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong SAR, China, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong SAR, China, 3 Center for Neural Science, New York University, New York, NY, United States

The BOLD response in the inferior colliculus (IC) was stronger to the forward than to the inverted vocalizations despite their identical frequency spectrum, clearly demonstrating response selectivity. The selectivity was prominent in the external cortex of IC, but was not observed in the lateral lemniscus (LL). The response selectivity was nearly abolished following atropine injection. The results suggest that the auditory midbrain is the first place in the ascending auditory pathway to display response selectivity to vocalizations, and highlights the ability of fMRI in investigating the processing of behaviorally relevant sounds.

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