fMRI Demonstrates Response Selectivity to the Behaviorally Relevant Sounds in the Midbrain
Jevin W. Zhang 1,2 , Patrick P. Gao 1,2 , Shu-Juan Fan 1,2 , Dan H. Sanes 3 , and Ed X. Wu 1,2
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, Hong
Kong SAR, China,
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong SAR, China,
for Neural Science, New York University, New York, NY,
The BOLD response in the inferior colliculus (IC) was
stronger to the forward than to the inverted
vocalizations despite their identical frequency
spectrum, clearly demonstrating response selectivity.
The selectivity was prominent in the external cortex of
IC, but was not observed in the lateral lemniscus (LL).
The response selectivity was nearly abolished following
atropine injection. The results suggest that the
auditory midbrain is the first place in the ascending
auditory pathway to display response selectivity to
vocalizations, and highlights the ability of fMRI in
investigating the processing of behaviorally relevant
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