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Abstract #1304

Cortical Modulation of Binaural Interaction on the Midbrain

Shu-Juan Fan 1,2 , Jevin W. Zhang 1,2 , Patrick P. Gao 1,2 , Dan H. Sanes 3 , and Ed X. Wu 1,2

1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong SAR, China, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong SAR, China, 3 Center for Neural Science, New York University, New York, NY, United States

Binaural interaction is important for recognizing complex sound cues. This preliminary fMRI study probed such cortical modulation effect in the major auditory midbrain structure, inferior colliculus, in experimental rodents with unilateral primary AC ablation. BOLD response is significantly lower to binaural stimulation than to uniaural stimulation, and such decrease was more obvious in the right IC than in the left IC. These results provide further evidence of descending modulation of binaural interaction from AC. Further experiments will be pursued in normal animals and other auditory disorders to shine light on the understanding of cortical modulation of binaural midbrain sound processing.

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