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Abstract #1305

Contrast and duration dependence of the negative BOLD response to visual stimulation in visual and auditory cortical regions at 7T

Joo Jorge 1,2 , Patrcia Figueiredo 2 , Rolf Gruetter 1,3 , and Wietske van der Zwaag 4

1 Laboratory for Functional and Metabolic Imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 2 Department of Bioengineering, Instituto Superior Tcnico, Lisbon, Portugal, 3 Department of Radiology, University of Lausanne and University of Geneva, Lausanne, Switzerland, 4 Biomedical Imaging Research Center, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

Negative BOLD responses to stimulation are often found in various brain regions, and growing evidence supports their association with neuronal deactivation. The aim of this study was to characterize, in humans, positive (PBRs) and negative BOLD responses (NBRs) to visual checkerboard stimulation of varying contrast and duration, focusing on NBRs occurring in both visual and auditory cortical regions. Across subjects, visual PBRs and both visual and auditory NBRs were found to significantly depend on stimulus contrast and duration. Interestingly, for stimulation periods above 16s, visual and auditory NBRs tended to exhibit earlier returns to baseline than the visual PBR.

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