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Abstract #1306

Accelerated 2D J -Resolved MRS through Non-Uniform Sampling and Iterative Soft Thresholding

Andrew Prescot 1 , Xianfeng Shi 2 , and Perry Renshaw 2,3

1 Department of Radiology, University of Utah, Salt Lake City, UT, United States, 2 Department of Psychiatry, University of Utah, Salt Lake City, UT, United States, 3 VISN 19 MIRECC, Salt Lake City, UT, United States

Two-dimensional (2D) proton ( 1 H) magnetic resonance spectroscopy (MRS) techniques effectively enhance spectral resolution by separating metabolite resonances over a 2D surface. However, full uniform sampling (FUS) of the indirectly detected frequency dimension requires long measurement times thus rendering the methods unsuitable for many clinical applications. The present work investigates the combination of non-uniform sampling (NUS) strategies and iterative soft thresholding to reduce measurement times associated with 2D J-resolved 1 H MRS data acquired from human brain. A quantitative assessment of FUS and NUS situations is presented, and our preliminary data suggests that total measurement time can be reduced to 25%.

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