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Abstract #1307

Developmental changes of neurochemical profile in rat retrosplenial cortex measured by in vivo 1 H-MRS

Hui Zhang 1 and Hao Lei 1

1 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China

In this work, we measured metabolic profile in rat retrosplenial cortex (RSC) at preadolescence, adolescence and adulthood with in vivo 1H-MRS.We found that the changes for NAA, Tau, Ins and tPC levels were statistically significant across all three developmental ages. While the development-related changes of GABA, Glu and tCr levels were statistically significant only between adulthood and adolescence. The increased Glu and GABA levels from adolescence to adulthood, suggestive of that this developmental stage may be the critical period for the maturation of glutamatergic/GABAergic neurotransmission and/or dendritic stabilization in rat RSC

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