Abstract #1307
Developmental changes of neurochemical profile in rat retrosplenial cortex measured by in vivo 1 H-MRS
Hui Zhang 1 and Hao Lei 1
1
State Key Laboratory of Magnetic Resonance
and Atomic and Molecular Physics, Wuhan Institute of
Physics and Mathematics, Chinese Academy of Sciences,
Wuhan, Hubei, China
In this work, we measured metabolic profile in rat
retrosplenial cortex (RSC) at preadolescence,
adolescence and adulthood with in vivo 1H-MRS.We found
that the changes for NAA, Tau, Ins and tPC levels were
statistically significant across all three developmental
ages. While the development-related changes of GABA, Glu
and tCr levels were statistically significant only
between adulthood and adolescence. The increased Glu and
GABA levels from adolescence to adulthood, suggestive of
that this developmental stage may be the critical period
for the maturation of glutamatergic/GABAergic
neurotransmission and/or dendritic stabilization in rat
RSC
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
