Abstract #1312
Preserved Whole Brain N-acetylaspartate during Mild Hypercapnia Challenge
Sanjeev Chawla 1 , Yulin Ge 1 , Hanzhang Lu 2 , Olga Marshall 1 , Ke Zhang 1 , Brian J Soher 3 , and Oded Gonen 1
1
Radiology, New York University Langone
Medical Center, New York, NY, United States,
2
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
States,
3
Radiology,
Duke University Medical Center, Durham, NC, United
States
To ascertain the effect of mild hypercapnia (5%carbon
dioxide) on whole brain N-acetylaspartate (WBNAA), and
brain hemodynamics, twelve healthy male adults underwent
non-localized whole-brain proton MR spectroscopy,
T2-relaxation under spin tagging and pseudo continuous
arterial spin labeling under both normocapnia and
hypercapnia conditions. There was non-significant 0.2%
change in WBNAA from normocapnia to hypercapnia
condition. However, there was significant increase in
global gray-matter cerebral blood flow (45.226.81
ml/100g/min vs 62.828.7 ml/100g/min) and venous
oxygenation (56.317.33% vs 72.04.17%) from norcapnia
to hypercapnia condition. Our study suggests that
neuronal metabolism and vascular hemodynamics may have
different response to mild hypercapnia.
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