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Abstract #1312

Preserved Whole Brain N-acetylaspartate during Mild Hypercapnia Challenge

Sanjeev Chawla 1 , Yulin Ge 1 , Hanzhang Lu 2 , Olga Marshall 1 , Ke Zhang 1 , Brian J Soher 3 , and Oded Gonen 1

1 Radiology, New York University Langone Medical Center, New York, NY, United States, 2 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 3 Radiology, Duke University Medical Center, Durham, NC, United States

To ascertain the effect of mild hypercapnia (5%carbon dioxide) on whole brain N-acetylaspartate (WBNAA), and brain hemodynamics, twelve healthy male adults underwent non-localized whole-brain proton MR spectroscopy, T2-relaxation under spin tagging and pseudo continuous arterial spin labeling under both normocapnia and hypercapnia conditions. There was non-significant 0.2% change in WBNAA from normocapnia to hypercapnia condition. However, there was significant increase in global gray-matter cerebral blood flow (45.226.81 ml/100g/min vs 62.828.7 ml/100g/min) and venous oxygenation (56.317.33% vs 72.04.17%) from norcapnia to hypercapnia condition. Our study suggests that neuronal metabolism and vascular hemodynamics may have different response to mild hypercapnia.

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