Abstract #1314
Specificity of task-active modulation of hippocampal glutamate in response to associative learning: A 1 H functional Magnetic Resonance Spectroscopy study
Jeffrey A. Stanley 1 , Ashley Burgess 1 , Dalal Khatib 1 , Karthik Ramaseshan 1 , Noa Ofen 1 , David R. Rosenberg 1 , and Vaibhav A. Diwadkar 1
1
Psychiatry and Behavioral Neurosciences,
Wayne State University, Detroit, MI, United States
Glutamate (Glu) plays a major role as an excitatory
neurotransmitter in the hippocampus and the purpose of
this study was to investigate whether Glu is modulated
in the hippocampus during associative learning but not
working memory (WM). Using H fMRS study design, results
provide the first ever evidence of neurochemical
dynamics of the in vivo Glu signal in the hippocampus.
Heightened hippocampal Glu signal was observed during
associative learning followed by decreasing levels in
response to learning proficiency. During the WM task,
which is a predominantly PFC task, did not show any
significant differences in hippocampal Glu compared to
baseline.
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