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Abstract #1314

Specificity of task-active modulation of hippocampal glutamate in response to associative learning: A 1 H functional Magnetic Resonance Spectroscopy study

Jeffrey A. Stanley 1 , Ashley Burgess 1 , Dalal Khatib 1 , Karthik Ramaseshan 1 , Noa Ofen 1 , David R. Rosenberg 1 , and Vaibhav A. Diwadkar 1

1 Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States

Glutamate (Glu) plays a major role as an excitatory neurotransmitter in the hippocampus and the purpose of this study was to investigate whether Glu is modulated in the hippocampus during associative learning but not working memory (WM). Using H fMRS study design, results provide the first ever evidence of neurochemical dynamics of the in vivo Glu signal in the hippocampus. Heightened hippocampal Glu signal was observed during associative learning followed by decreasing levels in response to learning proficiency. During the WM task, which is a predominantly PFC task, did not show any significant differences in hippocampal Glu compared to baseline.

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