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Abstract #1319

Group analysis of threshold-free cluster enhancement score with application to normal ageing white matter study by diffusion spectrum imaging

PIN-YU CHEN 1,2 , Yu-Ling Chang 3 , Yu-Jen Chen 1 , Yu-Chun Lo 1 , Yung-Chin Hsu 1 , and Wen-Yih I Tseng 1,4

1 Center For Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Taiwan, 2 Department of Life Science, National Taiwan University, Taipei, Taiwan, Taiwan, 3 Department of Psychology, National Taiwan University, Taipei, Taiwan, 4 Molecular Imaging Center, National Taiwan University, Taiwan, Taiwan

Diffusion MRI is a powerful tool to probe the microstructural integrity of the white matter. This study used template-based diffusion spectrum imaging (DSI) tractography to analyze the microstructural integrity of 74 fiber tracts over the whole brain, and applied TFCW to evaluate the age effect on the tract integrity. Detailed investigation of the fiber tracts shows that the patterns of the white matter degeneration are heterogeneous. Our study supports some previous DTI literature that the microstructural integrity of the ageing brain decreases with age and the frontal part of the brain is the most severe region. In conclusion, our study provides detailed degenerative patterns of the white matter tracts in normal ageing which can serve as a useful reference for neurodegenerative diseases.

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