Abstract #1319
Group analysis of threshold-free cluster enhancement score with application to normal ageing white matter study by diffusion spectrum imaging
PIN-YU CHEN 1,2 , Yu-Ling Chang 3 , Yu-Jen Chen 1 , Yu-Chun Lo 1 , Yung-Chin Hsu 1 , and Wen-Yih I Tseng 1,4
1
Center For Optoelectronic Medicine, National
Taiwan University College of Medicine, Taipei, Taiwan,
Taiwan,
2
Department
of Life Science, National Taiwan University, Taipei,
Taiwan, Taiwan,
3
Department
of Psychology, National Taiwan University, Taipei,
Taiwan,
4
Molecular
Imaging Center, National Taiwan University, Taiwan,
Taiwan
Diffusion MRI is a powerful tool to probe the
microstructural integrity of the white matter. This
study used template-based diffusion spectrum imaging
(DSI) tractography to analyze the microstructural
integrity of 74 fiber tracts over the whole brain, and
applied TFCW to evaluate the age effect on the tract
integrity. Detailed investigation of the fiber tracts
shows that the patterns of the white matter degeneration
are heterogeneous. Our study supports some previous DTI
literature that the microstructural integrity of the
ageing brain decreases with age and the frontal part of
the brain is the most severe region. In conclusion, our
study provides detailed degenerative patterns of the
white matter tracts in normal ageing which can serve as
a useful reference for neurodegenerative diseases.
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