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Abstract #1323

Altered antioxidant profile in the healthy elderly occipital and posterior cingulate cortices measured via 7 T 1 H MRS

Malgorzata Marjanska 1 , J. Riley McCarten 2 , Laura S Hemmy 2 , Dinesh K Deelchand 1 , and Melissa Terpstra 1

1 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2 Minneapolis VA Medical Center, Geriatric Research and Clinical Center, MN, United States

Oxidative stress occurs at an early stage of age related cognitive decline. Ascorbate (Asc, vitamin C) and glutathione (GSH) are key contributors to the antioxidant network. We utilized short echo time 1 H MRS at 7 T to reliably quantify these antioxidant concentrations in the aging brain in the occipital cortex and the posterior cingulate cortex, which is pertinent to the pathology of Alzheimers disease. Asc was higher and GSH lower in elder subjects in both brain regions. The Asc difference in the PCC were the most significant ( p = 1.8 x 10 -5 ). This work has important implications for ongoing development of antioxidant based diagnosis, prevention and treatment of cognitive decline.

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