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Abstract #1333

Determinants of iron accumulation in the normal ageing brain

Lukas Pirpamer 1 , Edith Hofer 1 , Paul Freudenberger 2 , Stephan Seiler 1 , Christian Langkammer 3 , Franz Fazekas 1 , Stefan Ropele 1 , and Reinhold Schmidt 1

1 Department of Neurology, Medical University of Graz, Graz, Styria, Austria, 2 Molecular Biology and Biochemistry, Medical University of Graz, Styria, Austria, 3 MGH/HST Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, United States

This study analyzed R2* relaxomentry data from 314 healthy volunteers in various gray matter regions of the brain with the goal to find determinants for brain-iron accumulation. 18 factors were analyzed, which were related to lifestyle, cerebrovascular risk factors, serum levels of iron and iron-associated gene-snips. BMI seemed to be the most relevant determinant for increased R2* values, especially in the hippocampus. This finding stands in line with the hypothesis that BMI is an independent risk factor for dementia.

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