Abstract #1333
Determinants of iron accumulation in the normal ageing brain
Lukas Pirpamer 1 , Edith Hofer 1 , Paul Freudenberger 2 , Stephan Seiler 1 , Christian Langkammer 3 , Franz Fazekas 1 , Stefan Ropele 1 , and Reinhold Schmidt 1
1
Department of Neurology, Medical University
of Graz, Graz, Styria, Austria,
2
Molecular
Biology and Biochemistry, Medical University of Graz,
Styria, Austria,
3
MGH/HST
Martinos Center for Biomedical Imaging, Harvard Medical
School, Boston, MA, United States
This study analyzed R2* relaxomentry data from 314
healthy volunteers in various gray matter regions of the
brain with the goal to find determinants for brain-iron
accumulation. 18 factors were analyzed, which were
related to lifestyle, cerebrovascular risk factors,
serum levels of iron and iron-associated gene-snips. BMI
seemed to be the most relevant determinant for increased
R2* values, especially in the hippocampus. This finding
stands in line with the hypothesis that BMI is an
independent risk factor for dementia.
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