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Abstract #1334

Iron content of functional networks in the aged human cortex

Valerie C. Anderson 1 , Manoj K. Sammi 1 , Yosef A. Berlow 1 , Jeffrey A. Kaye 2 , Joseph F. Quinn 2 , and William D. Rooney 1

1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2 Department of Neurology, Oregon Health & Science University, Portland, OR, United States

Brain iron concentration, [Fe], was quantified in 20 healthy subjects (63 plus-or-minus sign 9 yrs) based on 7T 1 H 2 O R 1 and R 2 measurements and relaxivity models that incorporate terms for both macromolecular volume fraction and [Fe]. Pial surface iron maps were prepared and the extent and spatial distribution of iron in 6 functional networks was determined. We find that [Fe] varies throughout the cortex in older individuals and is highest in frontoparietal and default networks. These findings suggest that the vulnerability of age-related changes in these networks may be related to increased iron content.

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