Abstract #1336
Short- and long-term effects of hormonal contraceptives use on the default mode network
Timo De Bondt 1,2 , Dirk Smeets 3 , Pim Pullens 4,5 , Wim Van Hecke 3 , Yves Jacquemyn 6,7 , and Paul M Parizel 4,5
1
Radiology, Antwerp University Hospital,
Antwerp, Antwerp, Belgium,
2
Radiology,
University of Antwerp, Antwerp, Antwerp, Belgium,
3
icoMetrix,
Leuven, Belgium,
4
Radiology,
Antwerp University Hospital, Antwerp, Belgium,
5
Radiology,
University of Antwerp, Antwerp, Belgium,
6
Gynaecology
and Obstaetrics, Antwerp University Hospital, Antwerp,
Belgium,
7
Gynaecology
and Obstaetrics, University of Antwerp, Antwerp, Belgium
Resting-state fMRI images were acquired in 18 women with
natural menstrual cycle (NC) during the follicular
phase. 19 Subjects using hormonal contraception (HC)
were scanned during pill free week and during pill
intake. Data were analyzed with spatially constrained
ICA. We show long term alterations in bilateral
cingulate gyrus due to HC use and short term effects in
bilateral insula. Our results support previous,
non-resting-state fMRI-based, literature. Importantly,
HC-use is never corrected for in this and other
MRI-subfields. Consequently, researchers introduce
heterogeneity in their data, which will lead to loss of
accuracy and precision.
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