Coupling between the Salience Network and Default-mode Network Predicts Task-induced Deactivation through Regional Glutamate and GABA Concentrations

The coupling between the salience network (SN) and the default mode network (assessed by the SN-PCC connectivity) was negatively correlated with the regional excitation and inhibition balance (expressed as ratio of glutamate over GABA R_Glu/GABA) in PCC. Both of the SN-PCC connectivity and the R_Glu/GABA predicted the working memory task-induced deactivation in the PCC. The mediation analysis showed the relationship between the SN-PCC coupling and PCC deactivation was completely mediated by the local balance of the excitation and inhibition R_Glu/GABA.

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