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Abstract #1339

Investigating Task-Based Activation and Functional Connectivity in the White Matter using fMRI at 3 Tesla

Don Marciel Ragot 1,2 , Erin Mazerolle 3 , and J. Jean Chen 1,4

1 Rotman Research Institute, Baycrest, Toronto, Ontario, Canada, 2 Engineering Science, University of Toronto, Ontario, Canada, 3 University of Calgary, Ontario, Canada, 4 Medical Biophysics, University of Toronto, Ontario, Canada

Recent studies have used BOLD to detect white-matter functional activation in the largest white matter structures in the brain while subjects are performing interhemispheric tasks. While these studies lay the foundation for white-matter fMRI, they also used custom acquisition techniques unavailable on most scanners. Also, they report focal brain activity, but do not assess functional connectivity. In this work, we investigate the feasibility of detecting white-matter activation using conventional gradient- or spin-echo EPI at 3 Tesla. Spin-echo EPI produced robust white-matter activation in the corpus callosum, but not gradient-echo. We also demonstrate task-related white-matter fMRI connectivity using spin-echo EPI.

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