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Abstract #1345

Physiological characterization of a robust survival rodent fMRI method

Hanbing Lu 1 , Julia K Brynildsen 1 , Li-Ming Hsu 1 , Thomas Ross 1 , Elliot A Stein 1 , and Yihong Yang 1

1 Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, MD, United States

Proper choice of anesthetics is of critical importance for the success of an fMRI experiment. An anesthetic regime that uses low dose of dexmedetomidine in combination with low dose of isoflurane, permitted fMRI data acquisition for several hours. The rat default mode brain network has been successfully identified with this preparation, indicating that this protocol minimally disturbs brain network functions. However, medetomidine is known to cause peripheral vasoconstriction, respiratory suppression and bradycardia, confounding the fMRI signal. The goal of this study is to systematically characterize and to optimize physiological conditions for fMRI experiment under this anesthetic regimen.

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