Does the interpretation of task-based BOLD activation in adolescent bipolar disorder require TRUST?
Arron W.S. Metcalfe 1 , Benjamin I. Goldstein 2,3 , David E. Crane 1 , Antonette Scavone 3 , Hanzhang Lu 4 , and Bradley J. MacIntosh 5,6
Brain Sciences, Sunnybrook Research
Institute, Toronto, Ontario, Canada,
& Pharmacology, University of Toronto, Ontario, Canada,
Sunnybrook Health Sciences Centre, Toronto, Ontario,
of Texas Southwestern Medical Center, Dallas, Texas,
of Medical Biophysics, University of Toronto, Ontario,
of Physical Sciences, Sunnybrook Research Institute,
Toronto, Ontario, Canada
Bipolar disorder (BD) is associated with both increased
cardiovascular disease (CVD) risk and medial-frontal
cortex dysfunction. Potential interaction between oxygen
availability and blood oxygen level dependent (BOLD)
signal during motor-inhibition was examined in BDs and
healthy controls. Base-rate cerebral venous oxygen
availability (Yv) was analyzed as a covariate. Yv group
means were similar. Lower Yv should be associated with
larger potential increase in task signal and this was
supported in distributed regions for both groups.
Importantly, a positive relationship emerged in task
related medial cortex only for BDs, possibly suggesting
dampened vascular response. Overall, model corrections
for Yv were modest.
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