Abstract #1346
Does the interpretation of task-based BOLD activation in adolescent bipolar disorder require TRUST?
Arron W.S. Metcalfe 1 , Benjamin I. Goldstein 2,3 , David E. Crane 1 , Antonette Scavone 3 , Hanzhang Lu 4 , and Bradley J. MacIntosh 5,6
1
Brain Sciences, Sunnybrook Research
Institute, Toronto, Ontario, Canada,
2
Psychiatry
& Pharmacology, University of Toronto, Ontario, Canada,
3
Psychiatry,
Sunnybrook Health Sciences Centre, Toronto, Ontario,
Canada,
4
University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
5
Department
of Medical Biophysics, University of Toronto, Ontario,
Canada,
6
Department
of Physical Sciences, Sunnybrook Research Institute,
Toronto, Ontario, Canada
Bipolar disorder (BD) is associated with both increased
cardiovascular disease (CVD) risk and medial-frontal
cortex dysfunction. Potential interaction between oxygen
availability and blood oxygen level dependent (BOLD)
signal during motor-inhibition was examined in BDs and
healthy controls. Base-rate cerebral venous oxygen
availability (Yv) was analyzed as a covariate. Yv group
means were similar. Lower Yv should be associated with
larger potential increase in task signal and this was
supported in distributed regions for both groups.
Importantly, a positive relationship emerged in task
related medial cortex only for BDs, possibly suggesting
dampened vascular response. Overall, model corrections
for Yv were modest.
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