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Abstract #1346

Does the interpretation of task-based BOLD activation in adolescent bipolar disorder require TRUST?

Arron W.S. Metcalfe 1 , Benjamin I. Goldstein 2,3 , David E. Crane 1 , Antonette Scavone 3 , Hanzhang Lu 4 , and Bradley J. MacIntosh 5,6

1 Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada, 2 Psychiatry & Pharmacology, University of Toronto, Ontario, Canada, 3 Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada, 4 University of Texas Southwestern Medical Center, Dallas, Texas, United States, 5 Department of Medical Biophysics, University of Toronto, Ontario, Canada, 6 Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

Bipolar disorder (BD) is associated with both increased cardiovascular disease (CVD) risk and medial-frontal cortex dysfunction. Potential interaction between oxygen availability and blood oxygen level dependent (BOLD) signal during motor-inhibition was examined in BDs and healthy controls. Base-rate cerebral venous oxygen availability (Yv) was analyzed as a covariate. Yv group means were similar. Lower Yv should be associated with larger potential increase in task signal and this was supported in distributed regions for both groups. Importantly, a positive relationship emerged in task related medial cortex only for BDs, possibly suggesting dampened vascular response. Overall, model corrections for Yv were modest.

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