Abstract #1350
Trait and State-Dependent Abnormalities of Bipolar Disorder Detected by Quantitative T1rho Mapping
Casey P. Johnson 1 , Lois A. Warren 2 , Gary E. Christensen 3 , Jess G. Fiedorowicz 2 , Vincent A. Magnotta 1 , and John A. Wemmie 2,4
1
Radiology, University of Iowa, Iowa City,
IA, United States,
2
Psychiatry,
University of Iowa, Iowa City, IA, United States,
3
Electrical
and Computer Engineering, University of Iowa, Iowa City,
IA, United States,
4
Veterans
Affairs Medical Center, Iowa City, IA, United States
Bipolar disorder is characterized by episodes of
depressed and manic mood states. Little is known about
what triggers and perpetuates these moods. We applied a
new technique to study mood states in bipolar disorder:
whole-brain quantitative T1ρ mapping. Average T1ρ maps
were compared between groups of 9 depressed, 15
euthymic, 11 manic, and 25 control participants.
Cerebellar T1ρ values were abnormally elevated in all
three mood states compared to controls. Furthermore,
putamen T1ρ values were reduced in depression compared
to euthymia and controls. These findings point to both
trait and mood-state-dependent abnormalities in bipolar
disorder, possibly due to abnormal metabolism.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
