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Abstract #1350

Trait and State-Dependent Abnormalities of Bipolar Disorder Detected by Quantitative T1rho Mapping

Casey P. Johnson 1 , Lois A. Warren 2 , Gary E. Christensen 3 , Jess G. Fiedorowicz 2 , Vincent A. Magnotta 1 , and John A. Wemmie 2,4

1 Radiology, University of Iowa, Iowa City, IA, United States, 2 Psychiatry, University of Iowa, Iowa City, IA, United States, 3 Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States, 4 Veterans Affairs Medical Center, Iowa City, IA, United States

Bipolar disorder is characterized by episodes of depressed and manic mood states. Little is known about what triggers and perpetuates these moods. We applied a new technique to study mood states in bipolar disorder: whole-brain quantitative T1ρ mapping. Average T1ρ maps were compared between groups of 9 depressed, 15 euthymic, 11 manic, and 25 control participants. Cerebellar T1ρ values were abnormally elevated in all three mood states compared to controls. Furthermore, putamen T1ρ values were reduced in depression compared to euthymia and controls. These findings point to both trait and mood-state-dependent abnormalities in bipolar disorder, possibly due to abnormal metabolism.

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