Abstract #1350
Trait and State-Dependent Abnormalities of Bipolar Disorder Detected by Quantitative T1rho Mapping
Casey P. Johnson 1 , Lois A. Warren 2 , Gary E. Christensen 3 , Jess G. Fiedorowicz 2 , Vincent A. Magnotta 1 , and John A. Wemmie 2,4
1
Radiology, University of Iowa, Iowa City,
IA, United States,
2
Psychiatry,
University of Iowa, Iowa City, IA, United States,
3
Electrical
and Computer Engineering, University of Iowa, Iowa City,
IA, United States,
4
Veterans
Affairs Medical Center, Iowa City, IA, United States
Bipolar disorder is characterized by episodes of
depressed and manic mood states. Little is known about
what triggers and perpetuates these moods. We applied a
new technique to study mood states in bipolar disorder:
whole-brain quantitative T1ρ mapping. Average T1ρ maps
were compared between groups of 9 depressed, 15
euthymic, 11 manic, and 25 control participants.
Cerebellar T1ρ values were abnormally elevated in all
three mood states compared to controls. Furthermore,
putamen T1ρ values were reduced in depression compared
to euthymia and controls. These findings point to both
trait and mood-state-dependent abnormalities in bipolar
disorder, possibly due to abnormal metabolism.
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