Abstract #1351
A pilot fMRI study of the effect of negative stressful factors on the onset of female depression
bian haiman 1 , ji shengzhang 2 , zhuo chunjun 3 , li gongying 4 , and ren junjie 2
1
the Fourth Central Hospital of Tianjin,
tianjin, tianjin, China,
2
the
Fourth Central Hospital of Tianjin, tianjin, China,
3
Tianjin
Anning Hospital, tianjin, China,
4
Department
of psychiatry, Jining Medical University, shandong,
China
If negative stressful life events (NSLEs), such as
bereavement, accidental disasters play a key role in the
onset and maintenance of depression?Our experiment
adopted a block pattern design and use a 3.0 T MRI
system to obtain the fMRI data. Our study found that
drug-nave female patients with their first major
depressive episode who had experienced NSLEs prior to
the onset of depression had abnormal activation of
several brain regions involved in emotional perception,
memory, evaluation, and regulation.These results were
consistent with the negative cognitive theory of
depression, which proposes that negative stimulation is
an important factor in the onset and maintenance of
depression.
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