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Abstract #1357

Global Brain Network Alterations in Post-Traumatic Stress Disorder and Post-Concussion Syndrome

D Rangaprakash 1 , Gopikrishna Deshpande 1,2 , D Narayana Dutt 3 , Thomas A Daniel 2 , Adam Goodman 2 , Jeffrey S Katz 1,2 , Nouha Salibi 1,4 , Thomas S Denney Jr 1,2 , and MAJ Michael N Dretsch 5,6

1 AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 2 Department of Psychology, Auburn University, Auburn, AL, United States, 3 Department of Medical Electronics, Dayananda Sagar College of Engineering, Bangalore, Karnataka, India, 4 MR R&D, Siemens Healthcare, Malvern, PA, United States, 5 National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, United States, 6 U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, United States

Global characterization of functional segregation and integration were obtained by estimating transitivity and global efficiency values from directional connectivity networks obtained from resting state fMRI data acquired in Soldiers with PTSD, with both post-concussion syndrome (PCS) and PTSD, and matched military controls. These measures were higher in controls compared to both PTSD and PCS+PTSD groups, suggesting abnormalities in functionally specialized modular structures as well as integration between such units in PTSD. However no significant differences were found between PTSD and PCS+PTSD groups, suggesting that there is localized impact on only certain brain regions in individuals with PCS.

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