Abstract #1357
Global Brain Network Alterations in Post-Traumatic Stress Disorder and Post-Concussion Syndrome
D Rangaprakash 1 , Gopikrishna Deshpande 1,2 , D Narayana Dutt 3 , Thomas A Daniel 2 , Adam Goodman 2 , Jeffrey S Katz 1,2 , Nouha Salibi 1,4 , Thomas S Denney Jr 1,2 , and MAJ Michael N Dretsch 5,6
1
AU MRI Research Center, Department of
Electrical and Computer Engineering, Auburn University,
Auburn, AL, United States,
2
Department
of Psychology, Auburn University, Auburn, AL, United
States,
3
Department
of Medical Electronics, Dayananda Sagar College of
Engineering, Bangalore, Karnataka, India,
4
MR
R&D, Siemens Healthcare, Malvern, PA, United States,
5
National
Intrepid Center of Excellence, Walter Reed National
Military Medical Center, Bethesda, MD, United States,
6
U.S.
Army Aeromedical Research Laboratory, Fort Rucker, AL,
United States
Global characterization of functional segregation and
integration were obtained by estimating transitivity and
global efficiency values from directional connectivity
networks obtained from resting state fMRI data acquired
in Soldiers with PTSD, with both post-concussion
syndrome (PCS) and PTSD, and matched military controls.
These measures were higher in controls compared to both
PTSD and PCS+PTSD groups, suggesting abnormalities in
functionally specialized modular structures as well as
integration between such units in PTSD. However no
significant differences were found between PTSD and
PCS+PTSD groups, suggesting that there is localized
impact on only certain brain regions in individuals with
PCS.
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