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Abstract #1360

Amygdala Functional Connectivity after Real-time fMRI Neurofeedback Emotional Training in Combat-Related PTSD

Raquel Phillips 1 , Vadim Zotev 1 , Kymberly Young 1 , Chung Ki Wong 1 , Brent Wurfel 1 , Matthew Meyer 1,2 , Frank Krueger 1,3 , Matthew Feldner 1,4 , and Jerzy Bodurka 1,5

1 Laureate Institute for Brain Research, Tulsa, OK, United States, 2 Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, 3 Dept. of Psychology, George Mason University, Fairfax, VA, United States, 4 Dept. of Psychological Science, University of Arkansas, Fayetteville, AR, United States, 5 College of Engineering, University of Oklahoma, Tulsa, OK, United States

We performed emotion regulation training in veterans with combat-related PTSD using real-time fMRI neurofeedback (rtfMRI-nf). Seven subjects in the experimental group learned to upregulate left amygdala activity using rtfMRI-nf based on retrieval of happy autobiographical memories, while seven subjects in the control group performed the rtfMRI-nf task with feedback from the left horizontal segment of the intraparietal sulcus. Functional connectivity analysis showed that for the experimental group activity in the left amygdala was more correlated with other regions of the brain during positive memory recall following three sessions of neurofeedback than it was in the control group.

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