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Abstract #1359

Assessment of Stress-induced Neurochemical Alterations in a Rat Model of Chronic Stress using in vivo 1 H MRS at 11.7 Tesla

Fawzi Boumezbeur 1 , Riccardo Magalhes 2 , Ashley Novais 2 , Sbastien Mriaux 1 , Michel Bottlaender 1 , Arnaud Cachia 3 , Thrze Jay 3 , and Nuno Sousa 2

1 NeuroSpin, DSV/I2BM, Commissariat l'Energie Atomique, Gif-sur-Yvette, France, 2 ICVS/3B's-PT, School of Health Sciences, University of Minho, Braga, Portugal, 3 Inserm U894, Center for Psychiatry and Neurosciences, University Paris-Descartes, Paris, France

In this study, stress-induced neurochemical alterations were explored in the hippocampus of chronically stressed rats using in vivo 1 H MRS at 11.7 T; concomitantly potential correlations with the plasma level of corticosterone as a biomarker of stress were investigated. Our observations are consistent with a moderate neuronal metabolic stress (NAA: -3%) and the up-regulation of GABAergic neurotransmission (GABA: +14%) to limit the HPA axis hyperactivation due to our 3 week-long chronic stress paradigm. Notably, resilience to longitudinal stress (i.e. low corticosterone) in stressed rats is associated to a likely neuroprotective glial activity (Glu/Gln: -27% and Ins: +7%).

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