Abstract #1359
Assessment of Stress-induced Neurochemical Alterations in a Rat Model of Chronic Stress using in vivo 1 H MRS at 11.7 Tesla
Fawzi Boumezbeur 1 , Riccardo Magalhes 2 , Ashley Novais 2 , Sbastien Mriaux 1 , Michel Bottlaender 1 , Arnaud Cachia 3 , Thrze Jay 3 , and Nuno Sousa 2
1
NeuroSpin, DSV/I2BM, Commissariat
l'Energie Atomique, Gif-sur-Yvette, France,
2
ICVS/3B's-PT,
School of Health Sciences, University of Minho, Braga,
Portugal,
3
Inserm
U894, Center for Psychiatry and Neurosciences,
University Paris-Descartes, Paris, France
In this study, stress-induced neurochemical alterations
were explored in the hippocampus of chronically stressed
rats using
in
vivo
1
H
MRS at 11.7 T; concomitantly potential correlations with
the plasma level of corticosterone as a biomarker of
stress were investigated. Our observations are
consistent with a moderate neuronal metabolic stress
(NAA: -3%) and the up-regulation of GABAergic
neurotransmission (GABA: +14%) to limit the HPA axis
hyperactivation due to our 3 week-long chronic stress
paradigm. Notably, resilience to longitudinal stress
(i.e. low corticosterone) in stressed rats is associated
to a likely neuroprotective glial activity (Glu/Gln:
-27% and Ins: +7%).
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