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Abstract #1368

Biophysical modeling of high field diffusion MRI demonstrates micro-structural aberration in Chronic Mild Stress (CMS) rat brain

Ahmad Raza Khan 1 , Andrey Chuhutin 1 , Brian Hansen 1 , Ove Wiborg 2 , Christopher D Kroenke 3 , and Sune Nrhj Jespersen 1

1 Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark, 2 Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark, 3 Advanced Imaging Research Center, Oregon Health & Science University, Beaverton, Oregon, United States

CMS is one of the leading causes of depression, but the underlying pathology can be verified only by microscopy. This study was performed on CMS model of rat to explore sensitivity of diffusion weighted MRI to microstructural alterations in different brain regions. We utilized biophysical modelling and diffusion kurtosis (DKI) imaging to characterize microstructural aberrations in CMS brains. The study reveals significant increases in neurite density and mean kurtosis, and significant decreases in MD and extracellular diffusivity in the prefrontal cortex. We conclude that biophysical modelling and DKI modalities are able to detect preclinical alterations in CMS brains.

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