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Abstract #1369

Disrupted modular organization of structural cortical network topology in new-onset pediatric epilepsy

Jie Zheng 1 , Rushi Rajyaguru 1 , Jeffery Riley 1 , Gultekin Gulsen 1 , Bruce Hermann 2 , and Jack Lin 1

1 University of California, Irvine, Irvine, California, United States, 2 University of Wisconsin School of Medicine and Public Health, Wisconsin, United States

Our structural brain network will change topologically with time. Our study focuses on revealing the difference between growing teenagers from healthy group and epilepsy group during brain network shaping procedure. A control study has been set up over the first two years after epilepsy onset among children with localization related epilepsy (LRE) group and idiopathic generalized epilepsy (IGE) group. Then we introduced graph theory method to demonstrate the difference of global graphical properties alternation among three groups. Based on our results, the new-onset pediatric epilepsy leads to abnormal neurodevelopment structural trajectories with less network efficiency and less optimal small world configuration.

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