Abstract #1369
Disrupted modular organization of structural cortical network topology in new-onset pediatric epilepsy
Jie Zheng 1 , Rushi Rajyaguru 1 , Jeffery Riley 1 , Gultekin Gulsen 1 , Bruce Hermann 2 , and Jack Lin 1
1
University of California, Irvine, Irvine,
California, United States,
2
University
of Wisconsin School of Medicine and Public Health,
Wisconsin, United States
Our structural brain network will change topologically
with time. Our study focuses on revealing the difference
between growing teenagers from healthy group and
epilepsy group during brain network shaping procedure. A
control study has been set up over the first two years
after epilepsy onset among children with localization
related epilepsy (LRE) group and idiopathic generalized
epilepsy (IGE) group. Then we introduced graph theory
method to demonstrate the difference of global graphical
properties alternation among three groups. Based on our
results, the new-onset pediatric epilepsy leads to
abnormal neurodevelopment structural trajectories with
less network efficiency and less optimal small world
configuration.
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