Abstract #1373
Different Epileptic Brain Networks in Unilateral Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis Identified by the Whole Brain Tract-Based Automatic and Surface-based Analyses
Yao-Chia Shih 1,2 , Yu-Jen Chen 2 , Yung-Chin Hsu 2 , Yu-Chun Lo 2 , Hong-Huei Liu 3 , and Wen-Yih Issac Tseng 2,4
1
Graduate Institute of Biomedical
Engineering, National Taiwan University, Taipei, Taipei,
Taiwan,
2
Center
for Optoelectronic Medicine, National Taiwan University
College of Medicine, Taipei, Taipei, Taiwan,
3
Department
of Neurology, National Taiwan University Hospital,
College of Medicine, National Taiwan University, Taipei,
Taipei, Taiwan,
4
Molecular Imaging Center,
National Taiwan University, Taipei, Taipei, Taiwan
Unilateral mesial temporal lobe epilepsy (MTLE) with HS
was regarded as a network disorder. In the present
study, we proposed a surface-based analysis and a
tract-specific analysis over the whole brain to detect,
respectively, the GM and WM alterations in unilateral
MTLE with HS. Since the sclerotic hippocampus may
generate epileptic activities and spread via the WM
tracts to other extratemporal regions, we hypothesized
that the WM alterations due to MTLE with HS might affect
the averaged cortical thickness of the connected GM
regions. In addition, we assumed that left and right
MTLE with HS should exhibit different epileptic
networks. Using the surfaced-based analysis and TBAA
method to assess, respectively, the WM and GM
alterations over the whole brain, this work demonstrated
different epileptic brain networks between left and
right MTLE with HS.
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