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Abstract #1374

MR-microscopy of human hippocampi: Multiparametric characterization of hippocampal sclerosis

Clarissa Gillmann 1 , Roland Coras 2 , Michael Uder 1 , Ingmar Blmcke 2 , and Tobias Buerle 1

1 Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 2 Institute of Neuropathology, University Hospital Erlangen, Erlangen, Germany

Purpose of this study was to investigate whether sclerotic and non-sclerotic hippocampal subfields can be discriminated by high-resolution, multiparametric MR-microscopy at 7T ex vivo. T1-, T2- and T2*-relaxation times, apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were determined in hippocampal subfields CA1-CA4 for both, a resected non-sclerotic and a resected sclerotic hippocampus. On morphologic images, distinct differences in the pyramid cell layer between both hippocampi are clearly visible. With respect to multiparametric imaging, ADC is most promising for differentiation of sclerotic and non-sclerotic subfields.

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