Abstract #1374
MR-microscopy of human hippocampi: Multiparametric characterization of hippocampal sclerosis
Clarissa Gillmann 1 , Roland Coras 2 , Michael Uder 1 , Ingmar Blmcke 2 , and Tobias Buerle 1
1
Institute of Radiology, University Hospital
Erlangen, Erlangen, Germany,
2
Institute
of Neuropathology, University Hospital Erlangen,
Erlangen, Germany
Purpose of this study was to investigate whether
sclerotic and non-sclerotic hippocampal subfields can be
discriminated by high-resolution, multiparametric
MR-microscopy at 7T ex vivo. T1-, T2- and T2*-relaxation
times, apparent diffusion coefficient (ADC) and
fractional anisotropy (FA) were determined in
hippocampal subfields CA1-CA4 for both, a resected
non-sclerotic and a resected sclerotic hippocampus. On
morphologic images, distinct differences in the pyramid
cell layer between both hippocampi are clearly visible.
With respect to multiparametric imaging, ADC is most
promising for differentiation of sclerotic and
non-sclerotic subfields.
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