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Abstract #1376

Graph-theoretical analysis of DTI reveals disruption in global and regional structural networks in children with localization-related epilepsy

Mojdeh Zamyadi 1 , Carter Snead 1 , Sam Doesburg 1 , Mary Lou Smith 1 , and Elysa Widjaja 2

1 Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada, 2 Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada

The aims of this study were to investigate the structural whole brain networks using graph theoretical measures in children with localization-related epilepsy, including subgroups with frontal and temporal lobe epilepsy relative to healthy controls. We also assessed the relation between graph measures of structural connectivity with and intelligence quotient (IQ) as well as other clinical parameters. We found disruption in global and regional networks, and reduced connectivity between multiple lobes in children with localization-related epilepsy. No associations was found between global network properties, IQ and clinical parameters.

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