Abstract #1376
Graph-theoretical analysis of DTI reveals disruption in global and regional structural networks in children with localization-related epilepsy
Mojdeh Zamyadi 1 , Carter Snead 1 , Sam Doesburg 1 , Mary Lou Smith 1 , and Elysa Widjaja 2
1
Neurosciences and Mental Health, The
Hospital for Sick Children, Toronto, Ontario, Canada,
2
Diagnostic
Imaging, The Hospital for Sick Children, Toronto,
Ontario, Canada
The aims of this study were to investigate the
structural whole brain networks using graph theoretical
measures in children with localization-related epilepsy,
including subgroups with frontal and temporal lobe
epilepsy relative to healthy controls. We also assessed
the relation between graph measures of structural
connectivity with and intelligence quotient (IQ) as well
as other clinical parameters. We found disruption in
global and regional networks, and reduced connectivity
between multiple lobes in children with
localization-related epilepsy. No associations was found
between global network properties, IQ and clinical
parameters.
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